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Issue 10, Volume 4, October 2007
Print ISSN: 1109-9518
E-ISSN: 2224-2902







Title of the Paper: Joint Experimental and Theoretical Investigation of the Propensity of Peptoids as Drug Carriers


Authors: Tina Schröder, Aina Quintilla, Julia Setzler, Esther Birtalan, Wolfgang Wenzel, Stefan Bräse

Abstract: Transport across the membrane is one of the key obstacles drug molecules must overcome to effectively function in the cell. Potential drugs should therefore be designed taking into account these specific membrane-transport properties. Here we investigate, both experimentally and by simulation, one promising class of molecules. Peptoids are structural analogs of the amino acids that make up the proteins of the cell. They constitute a very promising class of drug carriers because they are known to cross several biological barriers and, unlike proteins, they are unaffected by proteases. All-atom molecular dynamics simulations demonstrate that even short peptoid molecules exist in a rapidly fluctuating conformational ensemble, which differentially presents hydrophobic and hydrophilic molecular surface area to its environment, making these molecules well suited candidates for tunable membrane transport. In vivo studies showed that the synthesized peptoid Fluo-{6,6,6,6,6,6}-NH2 efficiently translocates into the cells and accumulates preferably in the cytosol.

Keywords: drug carrier, peptoid, membrane transport, specific accumulation, cytosol, molecular surface area, all-atom simulation

Title of the Paper: Practical Design of Intelligent Reminder System of Having Medicine for Chronic Patients


Authors: Chun-Liang Hsu, Sheng-Yuan Yang, Dong-Liang Lee, Lawrence Y.Deng

Abstract: This research is originally creative research, and already applied patent under authority of Patent Bureau of Taiwan (Authorized Invention number: I No.287982). People living in modern society are full of much pressure from all kinds of environment everyday and with the great change of dining habit people easily have many chronic diseases. In addition to causing huge damage to individual health, it also cost much society medical resource. Most chronic diseases need special care from nursing staff to remind of when to have the correct medicine. It is naturally proceeding in wards but patients usually forget to punctually have medicine once they leave the hospital and get back home, and this situation neglecting or forgetting to have medicine according to doctors’ instruction often causes many un-fortunate deaths of patients resulting in offsetting-less for individual and family. The research category of this study are including a medicine box as the main part of product which includes GSM module, speech-functional DSP, control panel displaying all information for patients, medicine detecting function, and a single chip microprocessor to operate the monitoring function. On the other hand, the interface of the commander terminal PC in nursing center, instructing all information for patients to punctually have medicine, is developed by us programming with VB language. The system function was verified completed successful and could be published for commercials for its creativity and practical purpose.

Keywords: GSM communication module, speech-functional DSP, Intelligent monitoring, Microprocessor, Interface

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