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Title of the Paper: Joint Experimental and Theoretical
Investigation of the Propensity of Peptoids as Drug Carriers
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Authors: Tina Schröder, Aina Quintilla, Julia Setzler,
Esther Birtalan, Wolfgang Wenzel, Stefan Bräse
Abstract: Transport across the membrane is one of the key obstacles drug molecules must overcome to effectively function in the cell.
Potential drugs should therefore be designed taking into account these specific membrane-transport properties. Here we investigate,
both experimentally and by simulation, one promising class of molecules. Peptoids are structural analogs of the amino acids that make
up the proteins of the cell. They constitute a very promising class of drug carriers because they are known to cross several biological
barriers and, unlike proteins, they are unaffected by proteases. All-atom molecular dynamics simulations demonstrate that even short
peptoid molecules exist in a rapidly fluctuating conformational ensemble, which differentially presents hydrophobic and hydrophilic
molecular surface area to its environment, making these molecules well suited candidates for tunable membrane transport. In vivo studies
showed that the synthesized peptoid Fluo-{6,6,6,6,6,6}-NH2 efficiently translocates into the cells and accumulates preferably in the
cytosol.
Keywords: drug carrier, peptoid, membrane transport, specific accumulation, cytosol, molecular surface area, all-atom simulation
Title of the Paper: Practical Design of Intelligent Reminder System of Having Medicine for
Chronic Patients
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Authors: Chun-Liang Hsu, Sheng-Yuan Yang,
Dong-Liang Lee, Lawrence Y.Deng
Abstract: This research is originally creative research, and already applied patent under authority of Patent
Bureau of Taiwan (Authorized Invention number: I No.287982). People living in modern society are full of
much pressure from all kinds of environment everyday and with the great change of dining habit people easily
have many chronic diseases. In addition to causing huge damage to individual health, it also cost much society
medical resource. Most chronic diseases need special care from nursing staff to remind of when to have the
correct medicine. It is naturally proceeding in wards but patients usually forget to punctually have medicine once
they leave the hospital and get back home, and this situation neglecting or forgetting to have medicine according
to doctors’ instruction often causes many un-fortunate deaths of patients resulting in offsetting-less for individual
and family. The research category of this study are including a medicine box as the main part of product which
includes GSM module, speech-functional DSP, control panel displaying all information for patients, medicine
detecting function, and a single chip microprocessor to operate the monitoring function. On the other hand, the
interface of the commander terminal PC in nursing center, instructing all information for patients to punctually
have medicine, is developed by us programming with VB language. The system function was verified completed
successful and could be published for commercials for its creativity and practical purpose.
Keywords: GSM communication module, speech-functional DSP, Intelligent monitoring, Microprocessor,
Interface
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